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Table 2 Top 5 genes associated with imaging phenotype using ISE variants only

From: Rare variants in the splicing regulatory elements of EXOC3L4 are associated with brain glucose metabolism in Alzheimer’s disease

Gene

Unique Loci

Variants across cohort

SKAT-O p-value

FDR corrected p-value

TNFAIP2

7

10

2.47E-05

0.123

STK35

56

148

3.09E-05

0.123

PWRN1

34

101

4.15E-05

0.123

EXOC3L4

8

21

6.11E-05

0.123

TMEM182

23

67

6.22E-05

0.123