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Table 2 Ten most significant results for primary open-angle glaucoma Metabochip-wide genetic associations in African Americans

From: Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records

CHR SNP Gene CA CAF OR 95% CI p-value
1 rs4846835 GALNT2 A 0.11 2.37 1.56–3.60 5.00 × 10− 5
1 rs34783939 GALNT2 C 0.15 2.09 1.44–3.02 8.73 × 10− 5
21 rs9982695 C21orf33 A 0.24 2.09 1.44–3.02 8.74 × 10− 5
4 rs3775202 VEGFC G 0.43 1.92 1.38–2.66 9.70 × 10−5
2 rs13423742 FN1 C 0.06 3.04 1.73–5.36 1.14 × 10− 4
6 rs7454156 BMP6 G 0.18 2.08 1.42–3.02 1.37 × 10− 4
6 rs9479726 RGS17-OPRM1 A 0.24 0.41 0.25–0.64 1.54 × 10−4
19 rs1671152 GP6 A 0.32 1.91 1.36–2.68 1.60 × 10−4
10 rs286489 LOC101929727 A 0.28 1.90 1.35–2.66 1.80 × 10−4
5 rs4336354 HTR4 G 0.09 2.51 1.54–4.07 1.86 × 10−4
  1. Logistic regression assuming an additive genetic model was performed for 138 cases and 1376 controls adjusted by age, sex, principal components, and median diastolic blood pressure. For the ten most significant associations, chromosome (CHR), SNP ID (rs number), gene, coded allele (CA), coded allele frequency (CAF), odds ratio (OR), 95% confidence interval (CI), and p-value are given