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Table 3 Primary open-angle glaucoma Metabochip-wide genetic associations in African Americans for dominant and recessive models that overlap with the most significant results for the additive genetic model

From: Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records

CHR

SNP

Gene

CA

OR

95% CI

p-value

Genetic model

1

rs4846835

GALNT2

A

2.43

1.56–3.74

6.59 × 10−5

dominant

1

rs34783939

GALNT2

C

2.24

1.47–3.39

1.6 × 10−4

dominant

2

rs13423742

FN1

C

2.82

1.63–4.86

2.02 × 10−4

dominant

6

rs9479726

RGS17-OPRM1

A

0.42

0.26–0.67

2.5 × 10−4

dominant

19

rs1671152

GP6

A

2.24

1.42–3.53

5.2 × 10−4

dominant

6

rs7454156

BMP6

G

5.14

2.54–10.37

4.87 × 10−6

recessive

  1. Logistic regression assuming a dominant genetic model adjusted by age, sex, principal components, and median diastolic blood pressure. Chromosome (CHR), SNP ID (rs number), gene, coded allele (CA), odds ratio (OR), 95% confidence interval (CI), p-value, and assumed genetic model are given
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BMC Medical Genomics

ISSN: 1755-8794

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