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Table 3 Primary open-angle glaucoma Metabochip-wide genetic associations in African Americans for dominant and recessive models that overlap with the most significant results for the additive genetic model

From: Local genetic ancestry in CDKN2B-AS1 is associated with primary open-angle glaucoma in an African American cohort extracted from de-identified electronic health records

CHR SNP Gene CA OR 95% CI p-value Genetic model
1 rs4846835 GALNT2 A 2.43 1.56–3.74 6.59 × 10−5 dominant
1 rs34783939 GALNT2 C 2.24 1.47–3.39 1.6 × 10−4 dominant
2 rs13423742 FN1 C 2.82 1.63–4.86 2.02 × 10−4 dominant
6 rs9479726 RGS17-OPRM1 A 0.42 0.26–0.67 2.5 × 10−4 dominant
19 rs1671152 GP6 A 2.24 1.42–3.53 5.2 × 10−4 dominant
6 rs7454156 BMP6 G 5.14 2.54–10.37 4.87 × 10−6 recessive
  1. Logistic regression assuming a dominant genetic model adjusted by age, sex, principal components, and median diastolic blood pressure. Chromosome (CHR), SNP ID (rs number), gene, coded allele (CA), odds ratio (OR), 95% confidence interval (CI), p-value, and assumed genetic model are given