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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

Fig. 4

Network analyses of NEFH and NEDD4. NEFH has been linked to TNF, IGF1 and MBP [58,59,60], which are all deafness genes in the mouse [58, 61, 62], and binds to OTOF [47], which is involved in deafness in mice and humans [48,49,50]. NEDD4 binds to and ubiquitylates the products of the mouse deafness genes PTEN, SPRY2 and IRS2 [63,64,65,66,67,68,69], and two proteins implicated in deafness in both mice and humans, WBP2 and KCNQ1 [26, 40,41,42,43,44]

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