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Table 2 Genes with very rare predicted pathogenic variants in more than one person

From: Whole exome sequencing in adult-onset hearing loss reveals a high load of predicted pathogenic variants in known deafness-associated genes and identifies new candidate genes

Number of individuals Genes      
12 MON1B      
11 TTN      
8 ADC NEFH ZAN    
7 DNAH2 GPR98 LRBA PAX2   
6 CHD3 DNAH3 MACF1 PTGER4 UBE2O NEB
  WDR19 ZMIZ2     
5 VWA5B1 DNAH8 HSPG2 DNAH1 CELSR3 PCNX
  DNAH7 PKHD1L1 TECTA ATG2A ATM RANBP17
  LRIG3 DNAH9 HECTD4 OBSCN VPS13B FAT2
  LAMA2 CAPN5 CDH23 WDR41   
4 DMD DUOX2 RBPJ USH2A MYO6 +52 a
3 COL11A1 NAV2 CPXM2 COL4A4 LRP2 MY015A
  MYH9 TSPEAR ACAN PCDH15 OTOG +160 a
2 WFS1 MECOM NTN1 GJB2 TCOF1 COL11A2
  CELSR1 SLC9A3R1 COL9A1 TJP2 ALMS1 JAG1
  ATP2B2 SLC26A4 LRIG1 LOXHD1 CHRNA9 RDX
  CHD7 NTF3 ELMOD3 SLC4A7 ATP8B1 NPC1
  KARS ERCC6 +745 a    
  1. Details of genes found to be mutated in multiple samples. Known deafness genes are in bold, and candidates for exclusion are underlined.
  2. aNumber of additional non-deafness genes with variants; only known deafness genes shown for these lists