Fig. 3
From: TAP: a targeted clinical genomics pipeline for detecting transcript variants using RNA-seq data
Simulation experiment to assess PAVFinder fusion calling performance in relation to sequencing coverage and other software. a. Design of experiment: reads simulated from fusion breakpoints and corresponding reference transcript sequences at different read depths are combined to simulate the titration series. b. Receiver Operating Characteristic (ROC) plots of PAVFinder, Tophat-Fusion [12], and deFuse [13] on 448 fusion events reported on TCGA data [39]