Table 2 Histopathological data and intrinsic subtypes of DCIS/IBC tumour samples included in the test-set (upper panel) and validation-set (lower panel; T = Tuebingen; M = Munich; n.d. = not done). The risk categories are calculated based on individual ROR (risk-of-recurrence) scores taking the lymph node status into account. For N0 patients, low-risk, ROR 0–40 (10-years distant recurrence rate < 10%), intermediate-risk, ROR 41–60 (10-years distant recurrence rate 11–20%), high-risk, ROR 61–100 (10-years distant recurrence rate > 20%). For N1 patients, low-risk, ROR 0–15, intermediate-risk, ROR 16–40, high-risk, ROR 41–100, Samples with an asterisk are similar to samples from the fresh frozen set
sample # | Age | T | Grade | N | M | ER | PR | HER2 | PAM50 intrinsic subtype (ROR) | Prosigna risk category |
|---|---|---|---|---|---|---|---|---|---|---|
Histopathological data and intrinsic subtypes of DCIS/IBC tumours of the test-set | ||||||||||
 T DCIS/IBC 1 | 52 | pT1c | G2 | pN0 | Mx | neg | neg | neg | luminal A (0) | low |
 T DCIS/IBC 2 | 73 | pT1c | G2 | pN0 | M0 | pos | pos | neg | luminal A (25) | low |
 T DCIS/IBC 3 | 52 | pT2 | G2 | pN0 | Mx | pos | pos | neg | luminal A (32) | low |
 T DCIS/IBC 4 | 66 | pT1c | G2 | pN0 | Mx | pos | neg | neg | luminal A (30) | low |
 T DCIS/IBC 5 | 67 | pT2 | G2 | pN1a | M0 | pos | pos | neg | luminal A (34) | low |
 T DCIS/IBC 6 | 68 | pT2 | G2 | pN2a | Mx | pos | pos | neg | luminal A (33) | low |
 T DCIS/IBC 7 | 45 | pT2 | G2 | pN1a | Mx | pos | pos | neg | luminal A (27) | low |
 T DCIS/IBC 8* | 57 | pT1 | G2 | pN0 | M0 | pos | pos | pos | luminal A (55) | intermediate |
 T DCIS/IBC 9* | 72 | pT1c | G3 | pN0 | M0 | pos | pos | neg | luminal B (80) | high |
 T DCIS/IBC 10 | 45 | pT1c | G2 | pN0 | M0 | neg | neg | neg | HER2-enriched (71) | high |
 T DCIS/IBC 11* | 74 | pT1c | G2 | pN2a | M0 | pos | pos | neg | HER2-enriched (93) | high |
 T DCIS/IBC 12* | 59 | pT2 | G2 | pN2a | M0 | neg | neg | neg | basal-like (64) | high |
 T DCIS/IBC 13 | 54 | pT2 | G3 | pN0 | M0 | neg | neg | neg | basal-like (59) | intermediate |
 T DCIS/IBC 14 | 49 | pT2 | G2 | pN1a | M0 | neg | neg | neg | n.d. | n.d. |
 T DCIS/IBC 15* | 66 | pT2 | G2–3 | pN0 | M0 | neg | neg | pos | n.d. | n.d. |
Histopathological data and intrinsic subtypes of DCIS/IBC tumours of the validation-set | ||||||||||
 M DCIS/IBC 1 | 51 | pT1c | G2 | pN0 | M0 | pos | pos | neg | luminal A (0) | low |
 M DCIS/IBC 2 | 62 | pT1b | G2 | pN0 | Mx | pos | neg | neg | luminal A (9) | low |
 M DCIS/IBC 3 | 58 | pT1b | G2 | pN0 | Mx | pos | pos | neg | luminal A (11) | low |
 M DCIS/IBC 4 | 45 | pT1c | G1 | pN0 | M0 | pos | pos | neg | luminal A (12) | low |
 M DCIS/IBC 5 | 62 | pT1b | G2 | pN0 | Mx | pos | pos | neg | luminal A (20) | low |
 M DCIS/IBC 6 | 67 | pT1c | G2 | pN0 | M0 | pos | pos | neg | luminal A (26) | low |
 M DCIS/IBC 7 | 45 | pT1b | G2 | pN0 | Mx | pos | pos | neg | luminal A (27) | low |
 M DCIS/IBC 8 | 63 | pT1c | G2 | pN0 | M0 | pos | pos | neg | luminal A (30) | low |
 M DCIS/IBC 9 | 45 | pT1b | G2 | pN0 | Mx | pos | pos | neg | luminal A (32) | low |
 M DCIS/IBC 10 | 59 | pT1c | G2 | pN0 | M0 | pos | pos | neg | luminal A (32) | low |
 M DCIS/IBC 11 | 68 | pT1b | G2 | pN0 | Mx | pos | pos | neg | luminal A (33) | low |
 M DCIS/IBC 12 | 54 | pT1a | G2 | pN0 | Mx | pos | pos | neg | luminal A (33) | low |
 M DCIS/IBC 13 | 61 | pT1b | G2 | pN0 | Mx | pos | pos | neg | luminal A (33) | low |
 M DCIS/IBC 14 | 60 | pT1c | G2 | pN0 | Mx | pos | pos | neg | luminal A (40) | low |
 M DCIS/IBC 15 | 65 | pT1c | G3 | pN0 | M0 | pos | pos | neg | luminal A (43) | intermediate |
 M DCIS/IBC 16 | 40 | pT1c | G2 | pN1a | M0 | pos | pos | neg | luminal A (30) | low |
 M DCIS/IBC 17 | 65 | pT1c | G2 | pN0 | M0 | pos | pos | neg | luminal A (53) | intermediate |
 M DCIS/IBC 18 | 58 | pT1c | G3 | pN0 | Mx | pos | pos | pos | luminal A (76) | high |
 M DCIS/IBC 19 | 67 | pT1c | G2 | pN2a | M0 | pos | pos | neg | luminal A (36) | low |
 M DCIS/IBC 20 | 42 | pT1b | G3 | pN1a | Mx | pos | pos | neg | luminal A (48) | intermediate |
 M DCIS/IBC 21 | 57 | pT1c | G3 | pN0 | M0 | pos | pos | neg | luminal A/B (31/58) | intermediate |
 M DCIS/IBC 22 | 51 | pT1c | G3 | pN0 | M0 | pos | pos | neg | HER2-enriched (77) | high |
 M DCIS/IBC 23 | 62 | pT1c | G3 | pN1mi | M0 | pos | pos | pos | HER2-enriched (77) | high |
 M DCIS/IBC 24 | 61 | pT1c | G2 | pN0 | M0 | pos | pos | neg | n.d. | n.d. |
 M DCIS/IBC 25 | 28 | pT1b | G3 | pN1a | Mx | neg | pos | pos | n.d. | n.d. |