Toward the precision breast cancer survival prediction utilizing combined whole genome-wide expression and somatic mutation analysis

Table 1 The top mutated genes in the TCGA 1044 breast cancer dataset

Gene A	Gene B	A Not B	B Not A	Both	Log Odds Ratio	Adjusted p-Value	Tendency
TP53	CDH1	338	125	9	−2.067	< 0.001	Mutual exclusivity
TP53	GATA3	336	116	11	−1.771	< 0.001	Mutual exclusivity
TP53	MAP3K1	336	79	11	−1.327	< 0.001	Mutual exclusivity
TP53	PIK3CA	265	266	82	−0.641	< 0.001	Mutual exclusivity
PIK3CA	CDH1	284	70	64	0.735	0.002	Co-occurrence
TP53	TTN	264	104	83	0.62	0.004	Co-occurrence
PIK3CA	KMT2C	296	55	52	0.75	0.006	Co-occurrence
TTN	KMT2C	154	74	33	0.846	0.007	Co-occurrence
PIK3CA	MAP3K1	303	45	45	0.798	0.008	Co-occurrence
TTN	MUC16	146	68	41	1.209	< 0.001	Co-occurrence

ISSN: 1755-8794