Fig. 4

Disease-free survival curves in precursor-B-ALL at the time of diagnosis based on NER score. Three Kaplan Meier plots were generated for Staal (A), Hogan (B), and the combined dataset (C). The shaded area represents the 95% CI for each curve. P values using the log-rank test for each dataset comparing the two curves are shown on each plot. (A) In the Staal dataset, the median disease-free survival time was 32 months for the low NER score cohort (n = 13) and 25 months in the high NER score cohort (n = 14). Log-rank HR for the high NER score cohort relative to the low NER score cohort was 1.869, 95% CI (0.854–4.091). (B) In the Hogan dataset, the median disease-free survival time was 43 months for the low NER score cohort (n = 23) and 26.5 months in the high NER score cohort (n = 26). Log-rank HR for the high NER score cohort relative to the low NER score cohort was 2.034, 95% CI (1.344–3.648). (C) In the combined dataset, the median disease-free survival time was 37.5 months for the low NER score cohort (n = 36) and 26.5 months for the high NER score cohort (n = 40). Log-rank HR for the high NER score cohort relative to the low NER score cohort was 2.008, 95% CI (1.256–3.211)