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Fig. 5 | BMC Medical Genomics

Fig. 5

From: Nucleotide excision repair is a predictor of early relapse in pediatric acute lymphoblastic leukemia

Fig. 5

Pediatric precursor-B-ALL relapse model in the context of NER gene expression. Red Triangles represent the early relapse subgroup (Staal n = 19, Hogan n = 27, total = 46). Red squares represent the late relapse subgroup (Staal n = 8, Hogan n = 22, total = 30). Blue circles represent all subgroups together (Staal n = 27, Hogan n = 49, total = 76). Upon subset analysis based on time to relapse, patients that relapsed in under 36 months (“early relapsers”) had significantly higher NER gene expression at time of diagnosis. In contrast, the patients that relapsed in greater than or equal to 36 months (“late relapsers”) had a significantly lower initial NER gene expression at diagnosis. Early relapsers did not change from diagnosis to relapse in overall NER gene expression. The late relapsers have a significant increase in NER gene expression from diagnosis to relapse. At relapse, all patients have the same level of NER gene expression. We can distinguish patients at diagnosis who will relapse early versus those who will relapse late as their gene expression separates them. We propose that NER gene expression can be used as an indicator of early vs. late relapse at the time of diagnosis

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