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Fig. 4 | BMC Medical Genomics

Fig. 4

From: Transposase mapping identifies the genomic targets of BAP1 in uveal melanoma

Fig. 4

Loci with calling card insertions are associated with BAP1-regulated genes. a Correlation of gene expression with genomic loci calling-card insertions. For genomic loci with > 5 insertions, a statistically significant fraction show changes in expression, based on RNA-Seq, following loss of BAP1. b Venn diagram showing the overlap between BAP1 target genes > 5 calling-card insertion peaks and genes for which expression changed significantly (p < 0.01) following BAP1 depletion, as assessed by RNA-Seq. c Gene ontology pathway analysis was performed on BAP1 target genes divided into sets that were up-regulated or down-regulated in response to BAP1 depletion. Only significant pathways are shown (p < 0.01). d Two highly significant (p < 0.001) molecular signatures were identified by Gene Set Enrichment Analysis of BAP1 calling-card target genes associated with gene expression response to BAP1 depletion: the Epithelial-to-Mesenchymal Transition (EMT) signature was associated with up-regulated genes; and the polycomb-mediated lysine27-trimethylation of histone H3 in Embryonic Stem Cells was associated with down-regulated genes

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