Fig. 5
The top 10 most desirable genes show a large discrepancy in their percentile ranks across studies. After ranking the genes in each study by desirability (using the iR-none analysis) and calculating their percentiles based on the number of unique ranks, the top 10 most desirable genes appear to show even greater variability in relative ranking across not just data type, but individual studies. All 10 genes are in the top 25% of the (smaller) proteomics study, but their relative rankings vary significantly in all other studies. Furthermore, while none of the genes are in the top 25% of the GWAS study [30], other studies, like one of the transcriptomics analyses [43], show a large range in relative rankings, with certain highly desirable genes ranked very high and others ranked very low