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Table 2  Count of prioritized disease pairs by eQTL RNA overlap for each tissue

From: Novel disease syndromes unveiled by integrative multiscale network analysis of diseases sharing molecular effectors and comorbidities

Tissue of eQTL associations INPUT OUTPUT
Distinct eQTL SNPs Distinct eQTL RNAs Distinct SNP-RNA associations Distinct diseases Prioritized disease pairs (FDR < 5%)
Adipose subcutaneous 620 489 2400 127 1581
Artery aorta 337 200 1264 96 1198
Artery tibial 492 365 1898 125 1331
Blood 270 117 1388 77 1191
Brain 188 50 554 67 448
Breast mammary tissue 238 83 987 80 970
Cells transformed fibroblasts 541 417 1485 123 799
Colon transverse 231 95 810 80 748
Esophagus mucosa 518 398 1927 126 1462
Esophagus muscularis 560 421 1856 135 1366
Heart atrial appendage 218 55 867 71 674
Heart left ventricle 378 199 1283 104 1201
Lung 154 138 416 68 45
Muscle skeletal 551 408 2240 130 1617
Nerve tibial 748 627 2497 134 1536
Pancreas 279 126 843 85 753
Skin 806 667 2669 155 1775
Stomach 202 64 779 68 676
Thyroid 857 793 2759 145 1484
Total (union of sets) 1721 2644 8033 188 2043