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Table 4 Transcription factors enriched in normal-specific modules that showed differentially expressed between AD and normal brain samples

From: Condition-specific gene co-expression network mining identifies key pathways and regulators in the brain tissue of Alzheimer’s disease patients

Differentially expressed TFs Module name TF target genes in the module
BCL6 N_M9 CSRNP3;RBFOX2;UBE2R2;THRAP3;NRXN1;OTUD7A;FNIP2
BCL6 N_M13 TRPC3;RSPO2;BTBD11;ITM2A;HS3ST1
JUND N_M9 GABRA1;CSRNP3;UBE2R2;CCNY;NRXN1;GTPBP8;RUNX1T1
JUND N_M30 CFH;C1S;MS4A4A;TNFSF13B
REPIN1 N_M9 MYLIP;RBFOX2;CCNY;RAB14;GABRA4;KLHL8;KIF1A;SRCIN1
CBFB N_M11 DSP;CAMK2D;PTGER3;ARHGAP6
TCF4 N_M12 CLEC3B;CD163;COL1A2;SLC13A4;C7;C1S;ADH1B;OGN;FBLN1;CD14;CES1
TCF4 N_M24 GSTM3;SLC13A4;C2ORF40;LRRC18;GOLM1;KCNJ13;SERPINF1;TYRP1;ABCA4;BUB1B;HTR2C;FBLN1;SULF1;CLDN2;PRLR;LOXL1;GHR;SLCO1B3;SOSTDC1;OTX2;HPD
EGR1 N_M15 WWC3;CORO6;UPP1;FRS3
SOX10 N_M23 RGS2;ALKBH5;SNX16;BDNF;HS3ST2
ZBTB7A N_M25 EGR2;NR4A3;FOSB;SIK1;FOS;JUNB
APEX1 N_M28 IGBP1;CLCN4;PHF20;UBE2D3;ZNF12