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Table 3 Examples of predicted miRNA-mRNA pairs validated by literature

From: Discovering functional impacts of miRNAs in cancers using a causal deep learning model

miRNAs Targes Function Reference
miR-146a/miR-146b EGFR Invasion and metastasis MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in ap-ERK-dependent manner in castration-resistant prostate cancer
MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma
miR-335 SOX4 Metastasis progression miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells
miR-17 CCND1 Cell cycle, cellular proliferation The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition
miR-20a CCND1 Cell cycle, cellular proliferation MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC
miR-374a/miR-374b WNT Cell metastasis MicroRNA-374a activates Wnt/ß-catenin signaling to promote breast cancer metastasis
MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16
miR-374a/miR-374b PTEN Cellular proliferation, survival and growth MicroRNA-374a activates Wnt/ß-catenin signaling to promote breast cancer metastasis
Increased miR-374b promotes cell proliferation and the production of aberrant glycosylated lgA1 in B cells of lgA nephropathy