Table 3 Examples of predicted miRNA-mRNA pairs validated by literature
From: Discovering functional impacts of miRNAs in cancers using a causal deep learning model
miRNAs | Targes | Function | Reference |
|---|---|---|---|
miR-146a/miR-146b | EGFR | Invasion and metastasis | MiR-146a suppresses tumor growth and progression by targeting EGFR pathway and in ap-ERK-dependent manner in castration-resistant prostate cancer MiR-146b-5p suppresses EGFR expression and reduces in vitro migration and invasion of glioma |
miR-335 | SOX4 | Metastasis progression | miR-335 orchestrates cell proliferation, migration and differentiation in human mesenchymal stem cells |
miR-17 | CCND1 | Cell cycle, cellular proliferation | The miR-17-5p microRNA is a key regulator of the G1/S phase cell cycle transition |
miR-20a | CCND1 | Cell cycle, cellular proliferation | MicroRNAs MiR-17, MiR-20a, and MiR-106b act in concert to modulate E2F activity on cell cycle arrest during neuronal lineage differentiation of USSC |
miR-374a/miR-374b | WNT | Cell metastasis | MicroRNA-374a activates Wnt/ß-catenin signaling to promote breast cancer metastasis MicroRNA-374b Suppresses Proliferation and Promotes Apoptosis in T-cell Lymphoblastic Lymphoma by Repressing AKT1 and Wnt-16 |
miR-374a/miR-374b | PTEN | Cellular proliferation, survival and growth | MicroRNA-374a activates Wnt/ß-catenin signaling to promote breast cancer metastasis Increased miR-374b promotes cell proliferation and the production of aberrant glycosylated lgA1 in B cells of lgA nephropathy |