Table 1 Significant genes and GO analysis of the co-expression networks of different melanoma subtypes

Subtype 1

RPS24 SNHG5 RPS3 RPL38

BP: cotranslational protein targeting

6.34E-8

RPL12 CTSB PAICS HLA-C

BP: translational initiation

2.89E-7

RPS12 MTRNR2L2 MTRNR2L6

BP: regulation of apoptotic process

9.71E-2

GAS5 MTRNR2L10 ARPC1B

KEGG: Antigen processing and presentation

8.47E-2

CC: focal adhesion

1.42E-3

Subtype 2

FOSB JUNB JUN IER2

BP: cellular response

2.28E-6

DNAJB1 TOB1 PPP1R15A

BP: negative regulation of transcription

7.67E-3

LOC284454 MCL1 BRD2

BP: regulation of cell death

3.025E-3

DUSP1 SLC2A3 ZFP36

MF: transcription factor activity

1.65E-4

KEGG: Osteoclast differentiation

4.96 E-4

Subtype 3

HLA-C CTSB HLA-B GSG1

BP: interferon signaling pathway

2.09E-12

IL12RB1 HLA-A CTSD

BP: positive regulation of T cell mediated cytotoxicity

2.96E-9

LOC90834 B2M HLA-F HLA-H

BP:antigen processing

1.38E-6

AHNAK HLA-E SHOX

BP: immune response

5.22E-11

KEGG:A ntigen processing and presentation

8.11E-8

Subtype 4

MTRNR2L6 MTRNR2L10

BP: cellular response to hormone stimulus

1.33E-2

MTRNR2L1 MTRNR2L3

BP: response to mechanical stimulus

1.50E-2

MTRNR2L2 MTRNR2L8

KEGG: Osteoclast differentiation

1.89E-2

FOSB IER2 MTRNR2L4

MF:DNA binding

8.34E-3

MTRNR2L7 ARGLU1

MF: transcription factor activity

6.79E-3

JUN RBM39 SET

Subtype 5

SHISA9 ABCC9 ORC4

KEGG: Cell cycle

5.28E-2

UGDH-AS1 LOC643406 ASTN2

CC: integral component of membrane

7.95E-2

MDM2 UGT8 LOC286437

CC: synapse

8.59E-2

TMEM212 XKR9 GLIPR1L2

SPC25 ARHGEF26-AS1

Subtype 6

C17orf76-AS1 RPS4X

BP:translational initiation

1.21E-18

RPS6 GAS5 RPL29

BP:rRNA processing

7.40E-17

RPS3 RPS24 RPS27

BP:ribosomal small subunit biogenesis

8.07E-5

EEF1G RPS19 RPLP0

MF:structural constituent of ribosome

1.76E-15

RPL18A RPL26 RPL13AP5

KEGG:Ribosome

2.44E-10