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Table 2 Variant detection replication analyses

From: “Omics” data integration and functional analyses link Enoyl-CoA hydratase, short chain 1 to drug refractory dilated cardiomyopathy

  Pearson’s Chi-squared tests with Yates’ continuity correction: p-value X-squared df
ECHS1 main effects
 Exon 1: rs10466126 and Exon 2: rs1049951    
 Exon 1: rs10466126 SNP and disease state 0.1718 1.8674 1
 Exon 2: rs1049951 SNP and disease state * < 2.2e-16 88.338 1
 Exon 1:rs10466126 (genotype level) and disease state 0.02082 7.7434 2
 Exon 2: rs1049951 (genotype) and disease state 1 0 1
 *rs10466126 (G/G) and disease state 0.02496 5.0269 1
 rs10466126 (A/G) and disease state 0.209 1.5782 1
Interactions
 Exon 1: rs10466126 SNP and Exon 2: rs1049951 SNP * < 2.2e-16 101.4085 1
 *Exon 2: rs1049951 (genotype) and Exon 1: rs10466126 (genotype) *2.82E-07 30.1636 7
 *rs10466126 (genotype), rs1049951 (genotype) and disease state * < 2.2e-16 382.4507 11
Exon 2: ECHS1 c.41insT main effects
 Exon 2: ECHS1 c.41insT (genotype) and disease state 0.3218 0.9816 1
Interactions
 Exon 2: rs1049951, Exon 1: rs10466126 and Exon 2: ECHS1 c.41insT * < 2.2e-16 147.8592 3
 Exon 1: rs10466126 and Exon 2: ECHS1 c.41insT 0.714 0.1343 1
 *Exon 2: rs1049951 and Exon 2: ECHS1 c.41insT *7.84E-08 28.8451 1
 *Exon 2: rs1049951 and Exon 2: ECHS1 c.41insT and disease state * < 2.2e-16 129.6056 3
DBT main effects
 rs12021720 and DCM 1 0 1
 rs12021720 (genotype) and DCM *0.3232 2.2589 2
Interactions
 DBT rs12021720 and ECHS1 rs10466126 0.005657 7.6566 1
 *DBT rs12021720 (genotype) and ECHS1 rs10466126 (genotype) *0.001096 18.2641 4
 DBT rs12021720, ECHS1 rs10466126, and DCM * < 2.2e-16 653.831 7
 *DBT rs12021720 (genotype) and ECHS1 rs10466126 (genotype) and DCM * < 2.2e-16 427.9155 17
  1. Legend: *Indicates Chi-squared test for probabilities p-values