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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Integration of genomic copy number variations and chemotherapy-response biomarkers in pediatric sarcoma

Fig. 1

Integration of genomic CNVs to chemotherapy-response for identification of predictive biomarkers of therapeutic response in pediatric sarcoma tumor biopsies and cell lines. a CNV patterns were detected in 206 sarcoma (OS, RMS, and ESFTs) patients as well as in 27 sarcoma cell lines (OS, RMS, and ESFTs). b The CNVs identified from sarcoma cells were also compared with the profile observed in the 206 sarcoma patients. c Frequent CNVs were identified by literature review from PUBMED and compared with 206 patients CNVs. d,e Large screening to evaluate drug response associated with CNVs using a Pearson Correlation calculation was completed to identify potential predictive biomarkers of therapeutic response in these sarcomas. f Matching sarcoma patients CNVs to sarcoma cells. g, h, i Significant predictive biomarkers of sensitivity and resistance to chemotherapy are obtained. Significant predictive biomarkers of sensitivity and resistance to chemotherapy will be identified for further exploration

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