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Table 1 Summary of the integrated regulatory relationships among miRNAs, TFs and genes

From: Network-based identification of critical regulators as putative drivers of human cleft lip

Relationship

Number of pairs

Number of miRNAs

Number of genes

Number of TFs

Methoda

miRNA-gene

77

9

37

/

A

miRNA-TF

21

8

/

12

A

TF-gene

671

/

126

27

B

TF-miRNA

76

17

/

22

B

Total

845

18

127

27

 
  1. aIn the Method column, (A) regulation relationships were supported by at least two of these databases: TargetScan, miRanda, PITA and miRTarBase; (B) TRANSFAC Match™ method was used for identification of TF-target relationship