Fig. 4
From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks
Associations of gene mutations to predicted drug response in TCGA – pan-cancer study. (a) Gene mutations significantly associated with predicted drug response across all TCGA samples. Here only the 11 genes with mutation rates larger than 10% were analyzed. Nodes labeled with names are those with extreme significance (adjust P < 1.0 × 10−200) and magnitude of ΔIC50 (ΔIC50 ≥ 0.7 or ΔIC50 < 0). (b, c) Examples of drugs modulated by TP53 and TTN mutations, respectively