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Table 2 Top mutations in modulating drug response among individual cancers

From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

Cancer Gene Mutation rate Num. modulated drugs Num. sensitive drugs Num. resistant drugs
LUAD TP53 46.1% 235 0 235
LUSC TP53 75.1% 228 0 228
STAD TP53 43.3% 224 0 224
HNSC TP53 66.1% 207 0 207
COAD TP53 55.7% 197 0 197
LIHC TP53 27.0% 194 1 193
BRCA TP53 32.2% 182 7 175
LGG IDH1 77.3% 159 138 21
PRAD TP53 10.8% 146 1 145
KIRC PBRM1 38.0% 142 3 139