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Table 4 Top GO clusters enriched in top 300 differentially expressed genes associated with predicted response to docetaxel

From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

GO ID GO term Num. genes P-value
Cluster 1 (enrichment score: 10.89)
GO:0007049 cell cycle 40 1.13 × 10−10
GO:0022402 cell cycle process 33 3.51 × 10− 10
GO:0000279 M phase 32 1.01 × 10−15
Cluster 2 (enrichment score: 3.96)
GO:0000166 nucleotide binding 56 1.95 × 10−4
GO:0032553 ribonucleotide binding 54 2.74 × 10−6
GO:0032555 purine ribonucleotide binding 54 2.74 × 10−6
Cluster 3 (enrichment score: 3.45)
GO:0000278 mitotic cell cycle 26 1.01 × 10− 9
GO:0051726 regulation of cell cycle 15 8.48 × 10−4
GO:0007346 regulation of mitotic cell cycle 12 3.09 × 10−5
Cluster 4 (enrichment score: 2.47)
GO:0051327 M phase of meiotic cell cycle 8 9.46 × 10−4
GO:0007126 meiosis 8 9.46 × 10−4
GO:0051321 meiotic cell cycle 8 1.07 × 10− 3
Cluster 5 (enrichment score: 2.07)
GO:0051276 chromosome organization 13 8.64 × 10−2
GO:0007059 chromosome segregation 6 9.34 × 10− 3
GO:0000070 mitotic sister chromatid segregation 5 2.45 × 10− 3
  1. Each cluster is represented by the largest three GO terms