Table 5 Top GO clusters enriched in top 300 differentially expressed genes associated with predicted response to CX-5461
From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks
GO ID | GO term | Num. genes | P-value |
|---|---|---|---|
Cluster 1 (enrichment score: 8.65) | |||
GO:0043062 | extracellular structure organization | 17 | 2.93 × 10−9 |
GO:0030198 | extracellular matrix organization | 15 | 4.55 × 10−10 |
GO:0005201 | extracellular matrix structural constituent | 13 | 2.64 × 10−9 |
Cluster 2 (enrichment score: 6.13) | |||
GO:0008544 | epidermis development | 18 | 2.35 × 10−9 |
GO:0007398 | ectoderm development | 18 | 7.71 × 10−9 |
GO:0030855 | epithelial cell differentiation | 8 | 4.60 × 10−3 |
Cluster 3 (enrichment score: 4.23) | |||
GO:0030199 | collagen fibril organization | 9 | 7.34 × 10−9 |
GO:0032963 | collagen metabolic process | 6 | 5.37 × 10−5 |
GO:0044259 | multicellular organismal macromolecule metabolic process | 6 | 8.96 × 10−5 |
Cluster 4 (enrichment score: 2.84) | |||
GO:0006928 | cell motion | 18 | 8.22 × 10−4 |
GO:0016477 | cell migration | 13 | 9.51 × 10−4 |
GO:0048870 | cell motility | 13 | 2.33 × 10−3 |
Cluster 5 (enrichment score: 2.60) | |||
GO:0060429 | epithelium development | 12 | 6.39 × 10−4 |
GO:0030855 | epithelial cell differentiation | 8 | 4.60 × 10−3 |
GO:0009913 | epidermal cell differentiation | 6 | 4.49 × 10−3 |