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Table 5 Top GO clusters enriched in top 300 differentially expressed genes associated with predicted response to CX-5461

From: Predicting drug response of tumors from integrated genomic profiles by deep neural networks

GO ID GO term Num. genes P-value
Cluster 1 (enrichment score: 8.65)
GO:0043062 extracellular structure organization 17 2.93 × 10−9
GO:0030198 extracellular matrix organization 15 4.55 × 10−10
GO:0005201 extracellular matrix structural constituent 13 2.64 × 10−9
Cluster 2 (enrichment score: 6.13)
GO:0008544 epidermis development 18 2.35 × 10−9
GO:0007398 ectoderm development 18 7.71 × 10−9
GO:0030855 epithelial cell differentiation 8 4.60 × 10−3
Cluster 3 (enrichment score: 4.23)
GO:0030199 collagen fibril organization 9 7.34 × 10−9
GO:0032963 collagen metabolic process 6 5.37 × 10−5
GO:0044259 multicellular organismal macromolecule metabolic process 6 8.96 × 10−5
Cluster 4 (enrichment score: 2.84)
GO:0006928 cell motion 18 8.22 × 10−4
GO:0016477 cell migration 13 9.51 × 10−4
GO:0048870 cell motility 13 2.33 × 10−3
Cluster 5 (enrichment score: 2.60)
GO:0060429 epithelium development 12 6.39 × 10−4
GO:0030855 epithelial cell differentiation 8 4.60 × 10−3
GO:0009913 epidermal cell differentiation 6 4.49 × 10−3
  1. Each cluster is represented by the largest three GO terms