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Table 1 Summary of identified significant associations in REGARDS study

From: A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

SNP ID Phenotype Minor allele (effect allele) Major Allele Beta or OR P-value MAF First reported in AAs
Matched phenotype
rs10096633 Triglycerides T C − 0.020 4.88E-10 0.4226  
rs1173727 Height T C 0.297 9.89E-08 0.2032 yes
rs12110693 Heart rate G A −1.302 4.28E-11 0.4984  
rs12740374 LDL Cholesterol T G −4.314 1.64E-10 0.2615  
rs173539 HDL Cholesterol T C 2.337 1.21E-19 0.3647 yes
rs1800775 HDL Cholesterol C A −2.843 1.53E-29 0.4272 yes
rs247616 HDL Cholesterol T C 4.309 4.88E-52 0.2528 yes
rs2794520 C reactive protein T C −0.125 3.92E-34 0.2146  
rs326 Triglycerides A G 0.019 8.20E-09 0.4436  
rs3764261 HDL Cholesterol A C 3.050 1.84E-30 0.3165  
rs6511720 LDL Cholesterol T G −5.624 1.19E-10 0.1337  
rs6511720 Total Cholesterol T G −6.143 3.14E-10 0.1337  
rs7412 LDL Cholesterol T C −15.870 2.17E-65 0.1114  
rs7499892 HDL Cholesterol T C −2.351 1.38E-19 0.3677 yes
rs7553007 C reactive protein A G −0.122 6.61E-34 0.2258  
rs876537 C reactive protein T C −0.124 7.99E-33 0.2083  
rs9398652 Heart rate C A −1.339 1.19E-11 0.4956  
Related phenotype
rs12740374 Dyslipidemia T G 0.783 1.08E-10 0.2615  
rs12740374 Total Cholesterol T G −4.152 3.24E-08 0.2615  
rs247616 Fram_CHD T C −0.041 3.78E-09 0.2528 yes
rs629301 Dyslipidemia G T 0.827 4.32E-08 0.3633  
rs646776 Dyslipidemia C T 0.827 4.41E-08 0.3622 yes
rs6511720 Dyslipidemia T G 0.737 4.45E-10 0.1337  
rs7412 Fram_CHD T C −0.066 3.03E-12 0.1114  
rs7412 Ideal7 T C 0.210 3.35E-14 0.1114  
rs7412 Dyslipidemia T C 0.525 6.16E-33 0.1114  
rs7412 Total Cholesterol T C −13.330 2.90E-37 0.1114  
rs7903146 Diabetes T C 1.306 2.30E-12 0.2919  
rs911119 Cystatin C C T −0.012 6.17E-08 0.356 yes
  1. Beta coefficients were showed for continuous variables and odd ratios (OR) were showed for binary variables. MAF: minor allele frequency. Matched phenotype means the same phenotype and SNP associations have been showed in previous published studies; if similar or related associations have been published before, they are defined as “related phenotype”. If this is the first time that an association was shown in Africa American population, “Yes” was given in the column” First reported in AAs “