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Table 1 Summary of identified significant associations in REGARDS study

From: A PheWAS study of a large observational epidemiological cohort of African Americans from the REGARDS study

SNP ID

Phenotype

Minor allele (effect allele)

Major Allele

Beta or OR

P-value

MAF

First reported in AAs

Matched phenotype

rs10096633

Triglycerides

T

C

− 0.020

4.88E-10

0.4226

 

rs1173727

Height

T

C

0.297

9.89E-08

0.2032

yes

rs12110693

Heart rate

G

A

−1.302

4.28E-11

0.4984

 

rs12740374

LDL Cholesterol

T

G

−4.314

1.64E-10

0.2615

 

rs173539

HDL Cholesterol

T

C

2.337

1.21E-19

0.3647

yes

rs1800775

HDL Cholesterol

C

A

−2.843

1.53E-29

0.4272

yes

rs247616

HDL Cholesterol

T

C

4.309

4.88E-52

0.2528

yes

rs2794520

C reactive protein

T

C

−0.125

3.92E-34

0.2146

 

rs326

Triglycerides

A

G

0.019

8.20E-09

0.4436

 

rs3764261

HDL Cholesterol

A

C

3.050

1.84E-30

0.3165

 

rs6511720

LDL Cholesterol

T

G

−5.624

1.19E-10

0.1337

 

rs6511720

Total Cholesterol

T

G

−6.143

3.14E-10

0.1337

 

rs7412

LDL Cholesterol

T

C

−15.870

2.17E-65

0.1114

 

rs7499892

HDL Cholesterol

T

C

−2.351

1.38E-19

0.3677

yes

rs7553007

C reactive protein

A

G

−0.122

6.61E-34

0.2258

 

rs876537

C reactive protein

T

C

−0.124

7.99E-33

0.2083

 

rs9398652

Heart rate

C

A

−1.339

1.19E-11

0.4956

 

Related phenotype

rs12740374

Dyslipidemia

T

G

0.783

1.08E-10

0.2615

 

rs12740374

Total Cholesterol

T

G

−4.152

3.24E-08

0.2615

 

rs247616

Fram_CHD

T

C

−0.041

3.78E-09

0.2528

yes

rs629301

Dyslipidemia

G

T

0.827

4.32E-08

0.3633

 

rs646776

Dyslipidemia

C

T

0.827

4.41E-08

0.3622

yes

rs6511720

Dyslipidemia

T

G

0.737

4.45E-10

0.1337

 

rs7412

Fram_CHD

T

C

−0.066

3.03E-12

0.1114

 

rs7412

Ideal7

T

C

0.210

3.35E-14

0.1114

 

rs7412

Dyslipidemia

T

C

0.525

6.16E-33

0.1114

 

rs7412

Total Cholesterol

T

C

−13.330

2.90E-37

0.1114

 

rs7903146

Diabetes

T

C

1.306

2.30E-12

0.2919

 

rs911119

Cystatin C

C

T

−0.012

6.17E-08

0.356

yes

  1. Beta coefficients were showed for continuous variables and odd ratios (OR) were showed for binary variables. MAF: minor allele frequency. Matched phenotype means the same phenotype and SNP associations have been showed in previous published studies; if similar or related associations have been published before, they are defined as “related phenotype”. If this is the first time that an association was shown in Africa American population, “Yes” was given in the column” First reported in AAs “
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BMC Medical Genomics

ISSN: 1755-8794

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