Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells

Table 10 Breakpoints detected within the AF9 non-SAR region in BA-treated TWO4 cells

BA-treated TWO4 cells	Breakpoint	Remarks
0.5 mM BA, pH 7.4	74,527
	74,629
	74,692
	74,696
	74,783
	74,878
	74,908	This chromosome break falls within a repeat CHARLIE5 (at coordinates 74,895–74,998).
	74,914	This chromosome break falls within a repeat CHARLIE5 (at coordinates 74,895–74,998).
	74,985	This chromosome break falls within a repeat CHARLIE5 (at coordinates 74,895–74,998).
0.5 mM BA, pH 5.8	74,578
	74,708
	74,766
	74,849
	74,953	This chromosome break falls within a repeat CHARLIE5 (at coordinates 74,895–74,998).
	74,987	This chromosome break falls within a repeat CHARLIE5 (at coordinates 74,895–74,998).
	75,043	This chromosome break falls within a repeat CHARLIE5 (at coordinates 75,006–75,169).

The nucleotide positions of the chromosome breaks detected within the AF9 gene were mapped according to the AF9 sequence accessed from Ensembl database [EMBL:ENSG00000171843]

ISSN: 1755-8794