Table 7 Breakpoints detected within the AF9 SAR region in BA-treated NP69 cells

0.5 mM BA, pH 7.4

This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported to translocate with the MLL gene leading to the formation of the MLL-AF9 fusion gene in an ALL patient [GenBank:AM050804].

This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported to translocate with the MLL gene leading to the formation of the MLL-AF9 fusion gene in an ALL patient [GenBank:AM050804].

This breakpoint is identical with a breakpoint identified in TWO4 cells treated with BA at pH 7.4. This chromosome break falls within the AF9 region (at coordinates 245,252–245,612) that was previously reported to be involved in the formation of the MLL-AF9 fusion gene in an ALL patient. This breakpoint is three nucleotides different from that reported in cultured normal blood cells treated with VP16 (at coordinate 245,593) [101], five nucleotides different from a breakpoint detected in H₂O₂-treated NP69 cells (at coordinate 245,591) and six nucleotides different from that identified in H₂O₂-treated HK1 cells (at coordinate 245,590) [97].

This chromosome break falls within a repeat ERE2_EH (at coordinates 245,627–245,728).

This chromosome break falls within a repeat ERE2_EH (at coordinates 245,627–245,728).

0.5 mM BA, pH 5.8

This breakpoint is nine nucleotides different from that identified in an ALL patient (at coordinate 245,612) [GenBank:AM050804].

This breakpoint is four nucleotides different from that reported in H₂O₂-treated NP69 cells (at coordinate 245,703) [97]. This chromosome break falls within a repeat ERE2_EH (at coordinates 245,627–245,728).

This breakpoint is five nucleotides different from that reported in H₂O₂-treated NP69 cells (at coordinate 245,703) [97]. This chromosome break falls within a repeat ERE2_EH (at coordinates 245,627–245,728).

This chromosome break falls within a repeat ERE2_EH (at coordinates 245,627–245,728).

This breakpoint is six nucleotides different from that reported in H₂O₂-treated NP69 cells (at coordinate 246,000) [97].