Matrix association region/scaffold attachment region: the crucial player in defining the positions of chromosome breaks mediated by bile acid-induced apoptosis in nasopharyngeal epithelial cells

Table 9 Breakpoints detected within the AF9 non-SAR region in BA-treated NP69 cells

BA-treated NP69 cells	Breakpoint	Remarks
0.5 mM BA, pH 7.4	74,653
	74,752
	74,775
	74,786
	75,013	This chromosome break falls within a repeat CHARLIE5 (at coordinates 75,006–75,169).
	75,081	This chromosome break falls within a repeat CHARLIE5 (at coordinates 75,006–75,169).
0.5 mM BA, pH 5.8	74,582
	74,636	Identical breakpoints detected in different IPCR replicates which were from two different sets of IPCR.
	74,784
	74,928	This chromosome break falls within a repeat CHARLIE5 (at coordinates 74,895–74,998).
	75,034	This chromosome break falls within a repeat CHARLIE5 (at coordinates 75,006–75,169).

The nucleotide positions of the chromosome breaks detected within the AF9 gene were mapped according to the AF9 sequence accessed from Ensembl database [EMBL:ENSG00000171843]

ISSN: 1755-8794