Skip to main content
Fig. 4 | BMC Medical Genomics

Fig. 4

From: Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

Fig. 4

Commonalities between GO terms enriched with budesonide-induced genes in A549, BEAS-2B and HBE cells. a. Budesonide-induced genes (≥ 2 fold, P ≤ 0.05; Additional file 5) in A549 (187 genes), BEAS-2B (240 genes), and HBE (86 genes) were each subjected to GO analysis using DAVID. Biological process and molecular function terms showing significant enrichment (EASE score ≤ 0.1) with each list, and also represented by at least 5 genes, were obtained (Additional file 7). The number of GO terms enriched in each cell variant is indicated and the Venn diagram illustrates the overlap in terms between each cell variant. Terms showing enrichment in HBE cells are provided to the right and are categorized (color coded) according to main function. b. This analysis was repeated using the lower stringency budesonide-induced gene lists, as defined in Fig. 3b, and the resultant GO terms are listed in Additional file 8. Total numbers of enriched GO terms for each cell variant are indicated and the Venn diagram illustrates overlap between terms in the 3 cell variants. To the right are the 24 GO terms that were enriched in common for all cell variants. These were categorized as in panel a

Back to article page