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Fig. 6 | BMC Medical Genomics

Fig. 6

From: Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

Fig. 6

Commonalities between GO terms enriched with the budesonide-repressed (≤0.5 fold, P ≤ 0.05) genes in A549, BEAS-2B and HBE cells. Budesonide-repressed genes (≤0.5 fold, P ≤ 0.05; Additional file 9) in each of A549 (108 genes), BEAS-2B (236 genes), and HBE (146 genes) were subjected to GO analysis using DAVID. Biological process and molecular function terms showing significant enrichment (EASE score ≤ 0.1) with each list, and represented by at least 5 genes, were obtained (Additional file 10). a. The number of GO terms enriched in the gene lists from each cell variant is indicated and overlaps are shown in the Venn diagram. The 14 GO terms enriched in common for all cell variants are shown. b. Three GO terms enriched in common in A549 and HBE cells, but not in BEAS-2B cells. c. Nineteen GO terms enriched in common in BEAS-2B and HBE cells, but not in A549 cells. d. Sixteen GO terms uniquely enriched in HBE cells. Each box (dotted lines in panels ad) also depicts the percentage of the genes associated with each term within the total number of genes repressed in HBE cells and the fold enrichment of each term in the HBE cell list. Significance, following correction for family-wide false discovery, in A549 (A), BEAS-2B (B), and HBE (H) cells, is indicated where: Benjamini ≤0.05 (*), Benjamini ≤0.01 (**), or Benjamini ≤0.001 (***)

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