Fig. 7

Comparison of budesonide-regulated genes in the three epithelial cell variants with those in airway tissue in vivo. Microarray analysis of A549 (N = 3), BEAS-2B (N = 4) and primary HBE (N = 4 donors) cells as well as airway tissue (N = 11 individuals) following budesonide exposure for 6 h identified 451 and 442 genes showing significant induction (≥ 2 fold, P ≤ 0.05) or repression (≤ 0.5 fold, P ≤ 0.05), respectively, compared to untreated control/placebo, in any of the cell variants or airway tissue. a. The 451 genes significantly induced (≥ 2 fold, P ≤ 0.05) by budesonide in any cell variant or airway tissue produced 15 groups showing overlaps as defined by the lower stringency, ≥ 1.25 fold cut-off, for each group. b. The 441 genes significantly repressed (≤ 0.5 fold, P ≤ 0.05) by budesonide in any cell variant or in airway tissue produce 15 groups showing overlaps, as defined by the lower stringency, ≤0.8 fold cut-off, for each group. Bars represent the number of genes within each group and below the genes in selected groups are listed. Genes within all groups are listed in Additional file 13 (for induced genes) and 13 (for repressed genes). Underlined genes represent genes that were in common between the cell variants using the stringent cut-off in Fig. 3 (for induced genes) and Fig. 5 (for repressed genes)