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Table 1 Top 20 pathways enriched by budesonide-induced genes in airway epithelial cell variants and tissue

From: Glucocorticoid-driven transcriptomes in human airway epithelial cells: commonalities, differences and functional insight from cell lines and primary cells

  1. Budesonide-induced genes ≥1.25 fold (P ≤ 0.05) in A549 (904 genes), BEAS-2B (1504 genes), HBE (757 genes), and airway tissue (553 genes) were subjected to KEGG pathway analysis using DAVID. KEGG pathways that were significantly enriched (EASE score ≤ 0.1) with each list and represented by at least 5 genes were obtained. The top 20 pathways, as defined by the product of the enrichment P values from all cells and tissue, are shown. Grey indicates significantly enriched pathways (EASE score ≤ 0.1). Black indicates pathways that are significantly enriched following family-wide false discovery rate correction (Benjamini ≤0.05). Pathways are sorted according to the product of P values in an ascending order. A = A549, B = BEAS-2B, H = HBE, and T = airway tissue (biopsy)