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Table 2 “Between Patient” Analysis: Association between a patient’s average value of the gene signature and their average value of each disease activity measurea,b

From: Association between changes in gene signatures expression and disease activity among patients with systemic lupus erythematosus

  IFN M1.2 IFN M3.4 IFN M5.12 BAFF LDG Plasma Cells
Estimate
(95% CI)
p value Estimate
(95% CI)
p value Estimate
(95% CI)
p value Estimate
(95% CI)
p value Estimate
(95% CI)
p value Estimate
(95% CI)
p value
PGA 0.05
(− 0.02, 0.12)
0.16 0.07
(− 0.00, 0.14)
0.064 0.08
(0.01, 0.16)
0.026 0.06
(− 0.02, 0.13)
0.15 0.06
(− 0.02, 0.13)
0.12 − 0.00
(− 0.08, 0.07)
0.90
SLEDAI 0.94
(0.68, 1.20)
< 0.0001 1.00
(0.73, 1.26)
< 0.0001 1.06
(0.80, 1.33)
< 0.0001 0.92
(0.64, 1.21)
< 0.0001 0.62
(0.32, 0.91)
< 0.0001 0.11
(− 0.21, 0.42)
0.50
SLEDAI Vascular 0.01
(− 0.01, 0.02)
0.50 0.01
(−0.01, 0.02)
0.81 −0.00
(− 0.02, 0.02)
0.92 0.00
(− 0.01, 0.02)
0.58 0.00
(− 0.02, 0.02)
0.98 0.01
(− 0.01, 0.03)
0.19
SLEDAI MUSCULOSKELETAL 0.02
(−0.00, 0.04)
0.062 0.03
(0.01, 0.05)
0.015 0.03
(0.01, 0.05)
0.0038 0.03
(0.01, 0.05)
0.013 0.03
(0.01, 0.05)
0.0099 0.00
(−0.02, 0.03)
0.74
SLEDAI Renal 0.01
(−0.03, 0.04)
0.70 0.01
(−0.03, 0.04)
0.61 0.02
(−0.02, 0.05)
0.35 0.01
(−0.03, 0.05)
0.57 0.02
(− 0.02, 0.05)
0.39 −0.03
(− 0.07, 0.01)
0.095
SLEDAI Skin 0.08
(0.03, 0.14)
0.0042 0.08
(0.03, 0.14)
0.0045 0.09
(0.03, 0.15)
0.0021 0.10
(0.04, 0.16)
0.0016 0.05
(− 0.00, 0.11)
0.069 −0.02
(− 0.08, 0.04)
0.57
SLEDAI Hematologic 0.01
(− 0.01, 0.04)
0.23 0.02
(− 0.01, 0.04)
0.17 0.01
(−0.01, 0.04)
0.35 0.00
(−0.02),0.03)
0.71 −0.02
(− 0.04, 0.01)
0.19 0.01
(− 0.02, 0.03)
0.44
SLEDAI Immunology) 0.30
(0.23, 0.37)
< 0.0001 0.32
(0.24, 0.39)
< 0.0001 0.34
(0.27, 0.42)
< 0.0001 0.27
(−.18, 0.35)
< 0.0001 0.17
(0.09, 0.25)
< 0.0001 0.06
(− 0.03, 0.15)
0.18
Urine Protein Creatinine Ratio −0.06
(− 0.16, 0.05)
0.29 − 0.06
(− 0.17, 0.05)
0.32 − 0.04
(− 0.15, 0.07)
0.50 − 0.09
(− 0.20, 0.03)
0.14 0.02
(− 0.09, 0.13)
0.74 − 0.05
(− 0.17, 0.07)
0.40
Log Anti-dsDNA 0.83
(0.60, 1.05)
< 0.0001 0.88
(0.65, 1.11)
< 0.0001 0.95
(0.72, 1.18)
< 0.0001 0.69
(0.44, 0.95)
< 0.0001 0.54
(0.30, 0.78)
< 0.0001 0.32
(0.05, 0.58)
0.019
C3 −11.9
(−16.2, −7.6)
< 0.0001 −13.0
(−17.4, −8.6)
< 0.0001 − 12.7
(− 17.1, − 8.3)
< 0.0001 −10.8
(− 15.5, −6.0)
< 0.0001 −1.7
(−6.3, 2.9)
0.46 −6.4
(− 11.3, − 1.6)
0.0099
C4 −2.28
(−3.44, − 1.13)
0.0001 −2.32
(−3.51, − 1.14)
0.0001 − 2.26
(− 3.46, − 1.06)
0.0002 −1.88
(− 3.15, − 0.61)
0.0038 − 0.72
(− 1.91, 0.48)
0.24 −1.05
(− 2.32, 0.23)
0.11
ESR 8.79
(5.86, 11.72)
< 0.0001 9.17
(6.18, 12.16)
< 0.0001 9.95
(6.95, 12.95)
< 0.0001 8.18
(4.93, 11.44)
< 0.0001 4.82
(1.69, 7.96)
0.0026 2.78
(− 0.59, 6.14)
0.11
  1. aThe entries in the table represent the expected difference in average disease activity measure per 1 standard deviation difference in average level of the gene signature. Bolded entries had p-values less than 0.05
  2. bAll the associations are adjusted for prednisone use, age, sex and race