Table 4 Top 15 canonical pathways by IPA
Canonical pathways | P-value | Genes |
|---|---|---|
Sirtuin Signaling Pathway | 0.0002 | PPARG,POLR1D,ATG12,TIMM44,ATG10, TIMM17B,MT-ND4,GLUD1,HIF1A,ESRRA, STAT3,MT-ND4L,AGTRAP,XPA,SOD3, SOD2,MT-ND3,GOT2 |
Leucine Degradation I | 0.0009 | AUH,IVD,HMGCL |
L-cysteine Degradation I | 0.0031 | CDO1,GOT2 |
Pyridoxal 5′-phosphate Salvage Pathway | 0.0038 | PAK1,SGK1,GRK6,GRK5,PKN1,IRAK1 |
Adipogenesis pathway | 0.0039 | PPARG,FOXC2,BMP4,HDAC11,CEBPA, XBP1,GTF2H5,SOX9,HIF1A |
IL-8 Signaling | 0.0062 | RAB11FIP2,GNAI3,ITGB2,CCND2,RND3, RHOD,MMP2,CHUK,LASP1,GNG12,IRAK1 |
Salvage Pathways of Pyrimidine Ribonucleotides | 0.0065 | NME3,PAK1,SGK1,GRK6,GRK5,PKN1, IRAK1 |
RhoGDI Signaling | 0.0081 | GNAI3,PAK1,PPP1R12C,ARHGAP9,RND3, PAK6,RHOD,CD44,GNG12,MSN |
Unfolded protein response | 0.0085 | PPARG,PDIA6,ERO1B,CEBPA,XBP1 |
Protein Ubiquitination Pathway | 0.0087 | PSMB4,UBE2G2,USP18,USP14,USP4, UCHL5,USP19,PSMD14,DNAJA1,UBE2D1, UBE2L6,UCHL3,UBE2J2 |
Superoxide Radicals Degradation | 0.0135 | SOD2,SOD3 |
Pyrimidine Ribonucleotides Interconversion | 0.0195 | NUDT5,NME3,ENTPD1,CTPS1 |
Ketogenesis | 0.0209 | BDH2,HMGCL |
Pyrimidine Ribonucleotides De Novo Biosynthesis | 0.0229 | NUDT5,NME3,ENTPD1,CTPS1 |
Dolichyl-diphosphooligosaccharide Biosynthesis | 0.0251 | DPM1,ALG8 |