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Table 4 Top 15 canonical pathways by IPA

From: Identification of biomarkers for amyotrophic lateral sclerosis by comprehensive analysis of exosomal mRNAs in human cerebrospinal fluid

Canonical pathways P-value Genes
Sirtuin Signaling Pathway 0.0002 PPARG,POLR1D,ATG12,TIMM44,ATG10, TIMM17B,MT-ND4,GLUD1,HIF1A,ESRRA, STAT3,MT-ND4L,AGTRAP,XPA,SOD3, SOD2,MT-ND3,GOT2
Leucine Degradation I 0.0009 AUH,IVD,HMGCL
L-cysteine Degradation I 0.0031 CDO1,GOT2
Pyridoxal 5′-phosphate Salvage Pathway 0.0038 PAK1,SGK1,GRK6,GRK5,PKN1,IRAK1
Adipogenesis pathway 0.0039 PPARG,FOXC2,BMP4,HDAC11,CEBPA, XBP1,GTF2H5,SOX9,HIF1A
IL-8 Signaling 0.0062 RAB11FIP2,GNAI3,ITGB2,CCND2,RND3, RHOD,MMP2,CHUK,LASP1,GNG12,IRAK1
Salvage Pathways of Pyrimidine Ribonucleotides 0.0065 NME3,PAK1,SGK1,GRK6,GRK5,PKN1, IRAK1
RhoGDI Signaling 0.0081 GNAI3,PAK1,PPP1R12C,ARHGAP9,RND3, PAK6,RHOD,CD44,GNG12,MSN
Unfolded protein response 0.0085 PPARG,PDIA6,ERO1B,CEBPA,XBP1
Protein Ubiquitination Pathway 0.0087 PSMB4,UBE2G2,USP18,USP14,USP4, UCHL5,USP19,PSMD14,DNAJA1,UBE2D1, UBE2L6,UCHL3,UBE2J2
Superoxide Radicals Degradation 0.0135 SOD2,SOD3
Pyrimidine Ribonucleotides Interconversion 0.0195 NUDT5,NME3,ENTPD1,CTPS1
Ketogenesis 0.0209 BDH2,HMGCL
Pyrimidine Ribonucleotides De Novo Biosynthesis 0.0229 NUDT5,NME3,ENTPD1,CTPS1
Dolichyl-diphosphooligosaccharide Biosynthesis 0.0251 DPM1,ALG8
  1. Enrichment of canonical pathway in DEGs was analyzed by Ingenuity Pathway Analysis (IPA). The top 15 ranked pathways are listed