Fig. 4

Complex events in dysplastic BE samples. a Complex events in sample HGD-2 (b) Complex events in HGD-3. For each sample, the upper panel shows a circos plot of structural variations (inner), B allele frequency (BAF), and copy number changes (green = loss, red = gain) according to chromosomal location (outer ring). The lower panels show events per chromosome (chromosome 8 in HGD-2 and chromosome 17 in HGD-3) with the top plot showing structural variations (colour coded according to the SV key shown); the second plot showing copy number changes (red = amplification, green = deletion). The third plot shows log10 inter-mutational distance between single nucleotide variants (colour coded according to the SNV key shown) with arrows indicating regions of kataegis. The fourth plot shows Log R ratio and the bottom plot shows BAF