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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets

Fig. 3

H3K18ac and H3K27ac were mapped post EGF treatment. a EGF was added for indicated times in serum starved SKBR3 cells. Chromatin was subjected to ChIP as indicated in the protocols (−/+SD). Enrichment was determined by using primers near the TSS of indicated genes. *p-value < 0.1 and **p-value <.01 t-test for significant difference between Untreated and EGF treated samples. b Total ChIP-seq peaks were counted for each condition and overlapping peaks were identified for each timepoint within each ChIP. c The location of each peak was determined using CEAS (sitepro) option. d H3K18ac and H3K27ac signals were mapped at all TSS by timepoint

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