Skip to main content
Fig. 5 | BMC Medical Genomics

Fig. 5

From: Transcriptomic and ChIP-sequence interrogation of EGFR signaling in HER2+ breast cancer cells reveals a dynamic chromatin landscape and S100 genes as targets

Fig. 5

EGF upregulates S100 gene family. a Bar graphs are log2 ratios of (timepoint/baseline). *p-value < 0.1, **p-value < .01, ***p-value < .001 as reported by Cufflinks b. IGB browser view at locus containing S100A6, S100A5, S100A4 and S100A3. Red arrows indicate locations near annotated TSS for S100 genes. c Pol2 enrichment at S100 genes before and 20 min after EGF treatment in HeLa cells using data from Gardini et al. [12]. d SKBR3 and BT474 cells were serum starved for 16 h and then treated with or without EGF for 24 h. RNA from those cells were used to examine the indicated the levels of S100A genes by RT-qPCR. The bars indicated relative levels of those S100A genes adjusted for 18S. Each bar was mean of three values plus standard deviation. **P < 0.01 compared to non-EGF treatment

Back to article page