Table 2 Rates of genotypes of analyzed genes in groups of patients with optimal and non-optimal response to TKI therapy
Gene and reference SNP | Reference allele | Variant allele | Patients with optimal response at 6 months (n = 32) | Patients with non-optimal response at 6 months (n = 30) | р-value | |||||
|---|---|---|---|---|---|---|---|---|---|---|
ANKRD35 rs11579366 | G | C | genotype | G/G | G/C | C/C | G/G | G/C | C/C | 0,16 |
rate, % | 9 | 50 | 41 | 29 | 39 | 32 | ||||
DNAH9 rs1990236 | G | A | genotype | G/G | G/A | A/A | G/G | G/A | A/A | 0,33 |
rate, % | 72 | 22 | 6 | 57 | 39 | 4 | ||||
MAGEC1 rs176037 | C | T | genotype | C/C | C/T | T/T | C/C | C/T | T/T | 0,68 |
rate, % | 53 | 20 | 27 | 41 | 32 | 27 | ||||
TOX3 rs10653661 | A | ATTTCT | genotype | A/A | A/ ATTTCT | ATTTCT/ ATTTCT | A/A | A/ ATTTCT | ATTTCT/ ATTTCT | 0,87 |
rate, % | 22 | 56 | 22 | 23 | 50 | 27 | ||||
THSD1 rs3803264 | G | A | genotype | G/G | G/A | A/A | G/G | G/A | A/A | 0,38 |
rate, % | 6 | 44 | 50 | 12 | 27 | 61 | ||||
MORN2 rs3099950 | G | A | genotype | G/G | G/A | A/A | G/G | G/A | A/A | 0,48 |
rate, % | 69 | 31 | 0 | 77 | 23 | 0 | ||||
PTCRA rs9471966 | G | A | genotype | G/G | G/A | A/A | G/G | G/A | A/A | 0,88 |
rate, % | 56 | 38 | 6 | 50 | 43 | 7 | ||||