Exome, transcriptome and miRNA analysis don’t reveal any molecular markers of TKI efficacy in primary CML patients

Table 6 List of selected miRNAs

Gene	Accession	Coefficient^a	p-value
hsa-miR-720	MIMAT0005954	−12.31	0.04
hsa-miR-1180	MIMAT0005825	−8.33	0.02
hsa-miR-92a-3p	MIMAT0000092	−7.58	0.03
hsa-miR-409-3p	MIMAT0001639	−3.06	0.03
hsa-miR-331-5p	MIMAT0004700	−2.68	0.01
hsa-miR-662	MIMAT0003325	−2.5	0.03
hsa-miR-891a	MIMAT0004902	−2.5	0.04
hsa-miR-548ah-5p	MIMAT0018972	− 2.22	0.01
hsa-miR-432-5p	MIMAT0002814	−2.2	0.03
hsa-miR-553	MIMAT0003216	1.32	0.02
hsa-miR-338-3p	MIMAT0000763	2.91	0.02
hsa-miR-450a-5p	MIMAT0001545	3.29	0.03
hsa-miR-145-5p	MIMAT0000437	3.48	0.01
hsa-miR-324-5p	MIMAT0000761	3.8	0.03
hsa-miR-181b-5p + hsa-miR-181d	MIMAT0000257	4.26	0.03
hsa-miR-181a-5p	MIMAT0000256	4.29	0
hsa-miR-221-3p	MIMAT0000278	5.49	0.02
hsa-miR-4286	MIMAT0016916	26.46	0.01

^aCoefficients below zero correspond to elevation of miRNA expression in optimal responders and coefficients above zero correspond to elevated miRNA expression in non-optimal responders

ISSN: 1755-8794