Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma

BMC Medical Genomics

Table 3 The results of functional analysis of missense mutations of ТР53

Mutation	Functional prediction			Activity of p53 protein in experiment in vitro [reference]
Mutation	PolyРhen-2 (description of mutation)	SIFT (description of mutation)	Mut_ass (degree of pathogenicity)	Activity of p53 protein in experiment in vitro [reference]
p.L130F	Probably pathogenic	Dangerous	High	Not active [44]
p.W146R	Non-pathogenic	Neutral	Low	Slightly reduced [44]
p.T155I	Probably pathogenic	Dangerous	Moderate	Not active [44,45,46]
p.R156C	Non-pathogenic	Neutral	Low	Hyperactive [37, 44]
p.R196Q	Probably pathogenic	Dangerous	High	Not active [38]
p.G244S	Probably pathogenic	Dangerous	Moderate	Not active [39, 45]
p.V272E	Probably pathogenic	Dangerous	High	Not active [44]
p.A276V	Probably pathogenic	Dangerous	Moderate	Not active [46]
p.G293R	Non-pathogenic	Neutral	Moderate	Slightly reduced [44]
p.A276V	Probably pathogenic	Dangerous	Moderate	Not active [38]
p.G293R	Non-pathogenic	Neutral	Moderate	Slightly reduced [44]

ISSN: 1755-8794