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Table 3 The results of functional analysis of missense mutations of ТР53

From: Clinical aspects of TP53 gene inactivation in diffuse large B-cell lymphoma

Mutation Functional prediction Activity of p53 protein in experiment in vitro
[reference]
PolyРhen-2
(description of mutation)
SIFT
(description of mutation)
Mut_ass
(degree of pathogenicity)
p.L130F Probably pathogenic Dangerous High Not active [44]
p.W146R Non-pathogenic Neutral Low Slightly reduced [44]
p.T155I Probably pathogenic Dangerous Moderate Not active [44,45,46]
p.R156C Non-pathogenic Neutral Low Hyperactive [37, 44]
p.R196Q Probably pathogenic Dangerous High Not active [38]
p.G244S Probably pathogenic Dangerous Moderate Not active [39, 45]
p.V272E Probably pathogenic Dangerous High Not active [44]
p.A276V Probably pathogenic Dangerous Moderate Not active [46]
p.G293R Non-pathogenic Neutral Moderate Slightly reduced [44]
p.A276V Probably pathogenic Dangerous Moderate Not active [38]
p.G293R Non-pathogenic Neutral Moderate Slightly reduced [44]