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Table 3 Change in plasma levels of adiponectin, chimerine, TNF-a and IL-6 in the study groups of patients

From: Interrelation of chemerin and TNF-α with mtDNA copy number in adipose tissues and blood cells in obese patients with and without type 2 diabetes

  Control group Pre-obese Patients with obesity
BMI, kg/m2 18,5 – 24,9 25–29,9 grade I obesity (30–34,9) grade II obesity (35–39,9) grade III obesity (› 40)
Without T2DM With T2DM Without T2DM With T2DM Without T2DM With T2DM
Groups 1 2 3 4 5 6 7 8
TNA-a pg/ml 2,03 (1,46 – 3,72) 1,92 (1,43 – 2,15) p1–2 = 0,47 4,07 (3,37 – 8,56) p1–3 = 0,03* p2–3 < 0,01* 20,16 (15,5 – 22,08) p1–4 < 0,01* p2–4 < 0,01* p3–4 < 0,01* 10,82 (5,68 – 13,89) p1–5 < 0,01* p2–5 < 0,01* p3–5 = 0,05 p4–5 < 0,01* 28,21 (19,2 – 40,19) p1–6 < 0,01* p2–6 < 0,01* p3–6 < 0,01* p4–6 = 0,02* p5–6 < 0,01* 14,71 (9,63 – 17,3) p1–7 < 0,01* p2–7 < 0,01* p3–7 < 0,01* p4–7 = 0,69 p5–7 = 0,06 p6–7 < 0,01* 32,86 (29,9 –34,16) p1–8 < 0,01* p2–8 < 0,01* p3–8 < 0,01* p4–8 < 0,01* p5–8 < 0,01* p6–8 = 0,84 p7–8 < 0,01*
Chemerin ng/ml 128 (117–147) 128,5 (103–157,5) p1–2 = 0,99 166 (147–172) p1–3 = 0,04* p2–3 = 0,03* 170,5 (151,5 – 179,5) p1–4 = 0,04* p2–4 = 0,04* p3–4 = 0,44 169 (148–177) p1–5 = 0,01* p2–5 = 0,03* p3–5 = 0,47 p4–5 = 0,93 150 (130,5 – 175,5) p1–6 = 0,10 p2–6 = 0,17 p3–6 = 0,75 p4–6 = 0,38 p5–6 = 0,53 190 (180–196) p1–7 < 0,01* p2–7 < 0,01* p3–7 = 0,04* p4–7 = 0,06 p5–7 = 0,049* p6–7 = 0,02* 143 (134–158) p1–8 = 0,05 p2–8 = 0,18 p3–8 = 0,26 p4–8 = 0,28 p5–8 = 0,16 p6–8 = 0,75 p7–8 < 0,01*
Adiponectin mkg/ml 3,54 (2,59 – 4,27) 1,74 (1,29 – 4,16) p1–2 = 0,18 2,27 (1,8 – 4,19) p1–3 = 0,25 p2–3 = 0,32 3,81 (2,87 – 4,14) p1–4 = 0,84 p2–4 = 0,15 p3–4 = 0,25 4,5 (1,9 – 5,48) p1–5 = 0,61 p2–5 = 0,07 p3–5 = 0,27 p4–5 = 0,99 3,67 (2,92–5,18) p1–6 = 0,61 p2–6 = 0,07 p3–6 = 0,28 p4–6 = 0,99 p5–6 = 0,98 4,44 (2,87–5,21) p1–7 = 0,39 p2–7 = 0,03* p3–7 = 0,15 p4–7 = 0,70 p5–7 = 0,69 p6–7 = 0,69 3,86 (1,85 – 4,71) p1–8 = 0,85 p2–8 = 0,11 p3–8 = 0,37 p4–8 = 0,88 p5–8 = 0,65 p6–8 = 0,65 p7–8 = 0,49
CRP mmol/l 4,41 (3,12–5,38) 1,8 (1,51 – 4,78) p1–2 = 0,058 1,9 (1,03 – 2,83) 7,72 (4,6 – 8,88) 7,6 (2,2 – 13,4) 5,7 (5,52 – 9,24) p2–6 = 0,036* 13,4 (9,9 – 15,99) p1–7 = 0,004* p2–7 = 0,0017* p3–7 = 0,01* 8,95 (5,04 – 14,34) p1–8 = 0,045* p2–8 = 0,004*
Glucose mmol/l 3,75 (1,7 – 5,24) 5,18 (4,98 – 5,34) p1–2 = 0,01* 5,6 (5,2 – 5,83) p1–3 = 0,02* 10,74 (9,74 – 10,88) p1–4 = 0,003* 5,8 (5,6 – 6,3) p1–5 = 0,002* 8,1 (6,7 – 11,8) p1–6 = 0,007* 5,9 (5,5 – 6,6) p1–7 = 0,01* 7,1 (5,8 – 9,6) p1–8 = 0,005*
Insulin ng/ml 47,09 (27,16 - 87,18) 45,06 (16,93 - 76,40) 60,62 (30,77 - 90,83) 84,67 (42,03 - 135,37) 176 (124–248) p = 0,01 139 (119–476) p = 0,035 216 (94,38 - 371,6) p = 0,033 304 (244–616) p = 0,001