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Table 3 Change in plasma levels of adiponectin, chimerine, TNF-a and IL-6 in the study groups of patients

From: Interrelation of chemerin and TNF-α with mtDNA copy number in adipose tissues and blood cells in obese patients with and without type 2 diabetes

  Control group Pre-obese Patients with obesity
BMI, kg/m2 18,5 – 24,9 25–29,9 grade I obesity (30–34,9) grade II obesity (35–39,9) grade III obesity (› 40)
Without T2DM With T2DM Without T2DM With T2DM Without T2DM With T2DM
Groups 1 2 3 4 5 6 7 8
TNA-a
pg/ml
2,03 (1,46 – 3,72) 1,92 (1,43 – 2,15)
p1–2 = 0,47
4,07 (3,37 – 8,56)
p1–3 = 0,03*
p2–3 < 0,01*
20,16 (15,5 – 22,08)
p1–4 < 0,01*
p2–4 < 0,01*
p3–4 < 0,01*
10,82 (5,68 – 13,89)
p1–5 < 0,01*
p2–5 < 0,01*
p3–5 = 0,05
p4–5 < 0,01*
28,21 (19,2 – 40,19)
p1–6 < 0,01*
p2–6 < 0,01*
p3–6 < 0,01*
p4–6 = 0,02*
p5–6 < 0,01*
14,71 (9,63 – 17,3)
p1–7 < 0,01*
p2–7 < 0,01*
p3–7 < 0,01*
p4–7 = 0,69
p5–7 = 0,06
p6–7 < 0,01*
32,86 (29,9 –34,16)
p1–8 < 0,01*
p2–8 < 0,01*
p3–8 < 0,01*
p4–8 < 0,01*
p5–8 < 0,01*
p6–8 = 0,84
p7–8 < 0,01*
Chemerin
ng/ml
128 (117–147) 128,5 (103–157,5)
p1–2 = 0,99
166 (147–172)
p1–3 = 0,04*
p2–3 = 0,03*
170,5 (151,5 – 179,5)
p1–4 = 0,04*
p2–4 = 0,04*
p3–4 = 0,44
169 (148–177)
p1–5 = 0,01*
p2–5 = 0,03*
p3–5 = 0,47
p4–5 = 0,93
150 (130,5 – 175,5)
p1–6 = 0,10
p2–6 = 0,17
p3–6 = 0,75
p4–6 = 0,38
p5–6 = 0,53
190 (180–196)
p1–7 < 0,01*
p2–7 < 0,01*
p3–7 = 0,04*
p4–7 = 0,06
p5–7 = 0,049*
p6–7 = 0,02*
143 (134–158)
p1–8 = 0,05
p2–8 = 0,18
p3–8 = 0,26
p4–8 = 0,28
p5–8 = 0,16
p6–8 = 0,75
p7–8 < 0,01*
Adiponectin
mkg/ml
3,54 (2,59 – 4,27) 1,74 (1,29 – 4,16)
p1–2 = 0,18
2,27 (1,8 – 4,19)
p1–3 = 0,25
p2–3 = 0,32
3,81 (2,87 – 4,14)
p1–4 = 0,84
p2–4 = 0,15
p3–4 = 0,25
4,5 (1,9 – 5,48)
p1–5 = 0,61
p2–5 = 0,07
p3–5 = 0,27
p4–5 = 0,99
3,67 (2,92–5,18)
p1–6 = 0,61
p2–6 = 0,07
p3–6 = 0,28
p4–6 = 0,99
p5–6 = 0,98
4,44 (2,87–5,21)
p1–7 = 0,39
p2–7 = 0,03*
p3–7 = 0,15
p4–7 = 0,70
p5–7 = 0,69
p6–7 = 0,69
3,86 (1,85 – 4,71)
p1–8 = 0,85
p2–8 = 0,11
p3–8 = 0,37
p4–8 = 0,88
p5–8 = 0,65
p6–8 = 0,65
p7–8 = 0,49
CRP
mmol/l
4,41 (3,12–5,38) 1,8 (1,51 – 4,78)
p1–2 = 0,058
1,9 (1,03 – 2,83) 7,72 (4,6 – 8,88) 7,6 (2,2 – 13,4) 5,7 (5,52 – 9,24)
p2–6 = 0,036*
13,4 (9,9 – 15,99)
p1–7 = 0,004*
p2–7 = 0,0017*
p3–7 = 0,01*
8,95 (5,04 – 14,34)
p1–8 = 0,045*
p2–8 = 0,004*
Glucose
mmol/l
3,75 (1,7 – 5,24) 5,18 (4,98 – 5,34)
p1–2 = 0,01*
5,6 (5,2 – 5,83)
p1–3 = 0,02*
10,74 (9,74 – 10,88)
p1–4 = 0,003*
5,8 (5,6 – 6,3)
p1–5 = 0,002*
8,1 (6,7 – 11,8)
p1–6 = 0,007*
5,9 (5,5 – 6,6)
p1–7 = 0,01*
7,1 (5,8 – 9,6)
p1–8 = 0,005*
Insulin
ng/ml
47,09 (27,16 - 87,18) 45,06 (16,93 - 76,40) 60,62 (30,77 - 90,83) 84,67 (42,03 - 135,37) 176 (124–248)
p = 0,01
139 (119–476)
p = 0,035
216 (94,38 - 371,6)
p = 0,033
304 (244–616)
p = 0,001