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Table 2 The content of markers of endothelial dysfunction (eNOS, ET-1, iCAM-1, vCAM-1, VEGF) and inflammatory mediators (TNF-α, IL-6, IL-8, CRP, leptin) in the serum of patients

From: The relationship between the mtDNA copy number in insulin-dependent tissues and markers of endothelial dysfunction and inflammation in obese patients

Mediators Control Patients without type 2 diabetes Patients with type 2 diabetes р-value
Nitrite (pg / ml) 3.57 (3.08–4.38) 3.68 (3.1–4.04) 4.03 (3.28–5.13) 0.5471
Endothelin-1 (pmol / L) 0.24 (0.17–0.32) 1.04 (0.32–4.16)* 0.49 (0.20–1.04) 0.02086*
iCAM-1 (pg / ml) 5667 (5117–5930) 5675 (5428–6058) 5856 (5450–6159) 0.4578
vCAM-1 (ng / ml) 11.03 (9.69–11.78) 11.63 (9.01–30.46) 33.76 (11.32–82.31)* 0.01768*
VEGF (pg / ml) 359.2 (249.3–468.9) 389.5 (181.7–570.3) 439.3 (264.2–625.4) 0.5606
TNF-a(pg / ml) 3.3 (2.65–4.77) 13.44 (8.21–14.94)* 32.6 (25.9–35)* < 0.001*
IL-6 (pg / ml) 1.35 (0.52–1.75) 3.06 (2.36–3.71)* 4.46 (3.53–6.16)* < 0.001*
IL-8 (pg / ml) 6.5 (4.7–9.7) 9.0 (7.54–10.62)* 9.19 (7.64–11.10)* 0.001429*
CRP(mmol / l) 3.56 (1.77–8.65) 13.39 (9.95–15.99)* 8.06 (3.54–14.23)* 0.002*
Leptin (ng / ml) 4.27 (2.90–8.20) 28.73 (18.1–49.9)* 40.83 (11.41–55.05)* < 0,001*
  1. Note: the significance is determined using the Kruskel-Wallis test for several independent samples (* - p < 0.05); The Mann-Whitney criterion for two independent samples (* - p < 0.05); * - differences from the control