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Table 2 The content of markers of endothelial dysfunction (eNOS, ET-1, iCAM-1, vCAM-1, VEGF) and inflammatory mediators (TNF-α, IL-6, IL-8, CRP, leptin) in the serum of patients

From: The relationship between the mtDNA copy number in insulin-dependent tissues and markers of endothelial dysfunction and inflammation in obese patients

Mediators

Control

Patients without type 2 diabetes

Patients with type 2 diabetes

р-value

Nitrite (pg / ml)

3.57 (3.08–4.38)

3.68 (3.1–4.04)

4.03 (3.28–5.13)

0.5471

Endothelin-1 (pmol / L)

0.24 (0.17–0.32)

1.04 (0.32–4.16)*

0.49 (0.20–1.04)

0.02086*

iCAM-1 (pg / ml)

5667 (5117–5930)

5675 (5428–6058)

5856 (5450–6159)

0.4578

vCAM-1 (ng / ml)

11.03 (9.69–11.78)

11.63 (9.01–30.46)

33.76 (11.32–82.31)*

0.01768*

VEGF (pg / ml)

359.2 (249.3–468.9)

389.5 (181.7–570.3)

439.3 (264.2–625.4)

0.5606

TNF-a(pg / ml)

3.3 (2.65–4.77)

13.44 (8.21–14.94)*

32.6 (25.9–35)*

< 0.001*

IL-6 (pg / ml)

1.35 (0.52–1.75)

3.06 (2.36–3.71)*

4.46 (3.53–6.16)*

< 0.001*

IL-8 (pg / ml)

6.5 (4.7–9.7)

9.0 (7.54–10.62)*

9.19 (7.64–11.10)*

0.001429*

CRP(mmol / l)

3.56 (1.77–8.65)

13.39 (9.95–15.99)*

8.06 (3.54–14.23)*

0.002*

Leptin (ng / ml)

4.27 (2.90–8.20)

28.73 (18.1–49.9)*

40.83 (11.41–55.05)*

< 0,001*

  1. Note: the significance is determined using the Kruskel-Wallis test for several independent samples (* - p < 0.05); The Mann-Whitney criterion for two independent samples (* - p < 0.05); * - differences from the control