The role of long non-coding RNAs in the pathogenesis of hereditary diseases

BMC Medical Genomics

Table 1 LncRNA participating in the pathogenesis of human hereditary diseases

Disease	LncRNA	Mechanism	reference
1. Angelman syndrome	UBE3A-ATS	Antisense transcription	[37]
2. Prader-willi syndrome	sno-lncRNAs	Splicing regulation	[40]
3. Beckwith-Wiedemann syndrome	KCNQ1OT1	Recruitment of chromatin-modifying complexes	[36]; [59]
4. Silver-Russell syndrome	H19	Recruitment of chromatin-modifying complexes; miRNA dependent mechanism	[51,52,53,54,55,56,57,58]
5.Pseudohypoparathyroidism type 1b	A\S-1	Antisense transcription	[63, 64]
	A\B	Antisense transcription	[61, 62]
6. Alzheimer disease	BACE1-AS	RNA-RNA duplex formation	[45]
	LPR1-AS	Recruitment of chromatin-modifying complexes	[68]
	51А	Splicing regulation	[42]
	17А	Splicing regulation	[73]
	ciRS −7	miRNA dependent mechanism	[75,76,77]
7. Huntington disease	HTTAS	miRNA dependent mechanism	[79]
8. Spinocerebellar ataxia type 7	SCAANT1	Antisense transcription	[39]
	lnc-SCA7	miRNA dependent mechanism	[83]
9. Spinocerebellar ataxia type 8	ATXN8OS	Splicing regulation	[41]
10. Facioscapulohumeral muscular dystrophy	DBE-T	Recruitment of chromatin-modifying complexes	[36]
11. Spinal muscular atrophy	SMN-AS1	Recruitment of chromatin-modifying complexes	[97]
12. Alpha thalassemia	LUC7	Antisense transcription	[99]
13. Opitz-Kaveggia syndrome	ncRNA-a	Recruitment of chromatin-modifying complexes	[102]
14. Hirschsprung disease	cir-ZNF609	miRNA dependent mechanism	[43]
15. Cartilage-hair hypoplasia	RMRP	miRNA dependent mechanism	[44]

ISSN: 1755-8794