Fig. 4

ML haplotypes evolution phylogenetic tree depicting ancestral state and allele frequencies distribution. Compressed 10-letters haplotypes exclude 2, 5, 7–9 positions according to small variation score between populations (Amova results: Table 2; Fig. 2). Frequencies comprise both first position alleles. The risk-associated alleles are colored by red. SNPs diverged from ancestral state are underlined. Bold type corresponds to first position altered in each of allele. The second position is the highest replicated allele rs1421085 (Table 1) affecting adipocyte metabolism (Claussnitzer et al., 2015)