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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Early gut microbiota signature of aGvHD in children given allogeneic hematopoietic cell transplantation for hematological disorders

Fig. 3

Gut microbiota variability at engraftment, in relation to aGvHD development. a PCoA based on Bray-Curtis distances of genus-level relative abundance profiles of samples collected at the engraftment from patients who did not develop aGvHD (green), who developed aGvHD (I-II grade) only involving the skin (gold), and who developed gastrointestinal aGvHD (II-IV grade) (dark red). Samples are identified by filled circles. First and second principal components (MDS1 and MDS2) are plotted, accounting for 26.2 and 10.4% of variance in the dataset, respectively. The biplot of the average bacterial coordinates weighted by the corresponding bacterial relative abundance per sample was superimposed on the PCoA plot for two of the bacterial genera contributing to the ordination space (arrows). b Box and whiskers distribution of the relative abundance (%) of OTUs assigned to the genus Bacteroides in samples collected before HSCT from subjects who did not develop aGvHD (green), who developed aGvHD (I-II grade) only involving the skin (gold), and who developed gastrointestinal aGvHD (II-IV grade) (dark red). Log2 fold changes of the main discriminant genera between pre-HSCT and engraftment samples in subjects who did not develop aGvHD (c), who developed aGvHD (I-II grade) only involving the skin (d), and who developed gastrointestinal aGvHD (II-IV grade) (e). Genera for which P ≤ 0.05 was obtained for at least one of the three groups of subjects are shown (please see Additional file 2: Table S1) (O., Oscillospira; F., Faecalibacterium; [Ru.], [Ruminococcus]; Ro., Roseburia; L., Lachnospira; D., Dorea; C., Coprococcus; Bl., Blautia; Bi., Bifidobacterium). Average values of log2 ratios are reported as bar plot, whereas dots identify the single values obtained for each subject included in each group. Filled black dots and bacterial names in bold are used when the abundance of the OTUs assigned to that genus was significantly different between pre-HSCT and engraftment samples (paired Wilcoxon test, P < 0.05), whereas empty circles are used when the difference was not significant

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