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Table 2 Result of the inbreeding analysis in cases where the total sum of the LCSH ≥ 3 suggest kinship of first to fourth grade of the proband's parents

From: Long contiguous stretches of homozygosity detected by chromosomal microarrays (CMA) in patients with neurodevelopmental disorders in the South of Brazil

Case

∑ of LCSH (Mbp)

Number of chromosomes involved

Number of LCSH blocks

Possible parental relationship

Degree of kinship

Coefficient of inbreeding (F)

LCSH (IBD) expected not tested (∼%)

#194

760

19

40

father (mother) / daughter (son); complete siblings

First

0.264

25

#271

334

12

22

half-brothers;

uncle (aunt)/niece (nephew); double first cousins; grandfather/granddaughter

Second

0.116

12,5

#297

314

13

25

0.109

12,5

#380

346

10

19

0.121

12,5

#220

402

18

30

0.139

12,5

#187

196

13

22

first cousins;

half uncle/niece

Third

0.068

6

#275

225

10

14

0.078

6

#395

136

12

17

0.047

6

#412

123

8

12

0.043

6

#413

162

13

18

0.056

6

#419

181

9

12

0.063

6

#354

193

10

14

0.067

6

#364

165

11

15

0.057

6

#157

62

9

9

first cousins once removed

fourth

0.022

3

#273

110

13

18

0.038

3

#287

96

6

9

0.033

3

#311

82

5

8

0.028

3

#378

93

13

8

0.032

3

  1. IBD Identity by descent