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Table 2 Result of the inbreeding analysis in cases where the total sum of the LCSH ≥ 3 suggest kinship of first to fourth grade of the proband's parents

From: Long contiguous stretches of homozygosity detected by chromosomal microarrays (CMA) in patients with neurodevelopmental disorders in the South of Brazil

Case of LCSH (Mbp) Number of chromosomes involved Number of LCSH blocks Possible parental relationship Degree of kinship Coefficient of inbreeding (F) LCSH (IBD) expected not tested (%)
#194 760 19 40 father (mother) / daughter (son); complete siblings First 0.264 25
#271 334 12 22 half-brothers;
uncle (aunt)/niece (nephew); double first cousins; grandfather/granddaughter
Second 0.116 12,5
#297 314 13 25 0.109 12,5
#380 346 10 19 0.121 12,5
#220 402 18 30 0.139 12,5
#187 196 13 22 first cousins;
half uncle/niece
Third 0.068 6
#275 225 10 14 0.078 6
#395 136 12 17 0.047 6
#412 123 8 12 0.043 6
#413 162 13 18 0.056 6
#419 181 9 12 0.063 6
#354 193 10 14 0.067 6
#364 165 11 15 0.057 6
#157 62 9 9 first cousins once removed fourth 0.022 3
#273 110 13 18 0.038 3
#287 96 6 9 0.033 3
#311 82 5 8 0.028 3
#378 93 13 8 0.032 3
  1. IBD Identity by descent