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Table 4 Cox proportional hazards model on TCGA dataset

From: Genes CEP55, FOXD3, FOXF2, GNAO1, GRIA4, and KCNA5 as potential diagnostic biomarkers in colorectal cancer

  Univariate analysis Multivariate analysis
  hazard ratio 95% confidence interval p-value hazard ratio 95% confidence interval p-value (p-value of model)
Cluster (CIMP vs. Non-CIMP (n = 180) 1.182 0.6763–2.065 0.5593    
Age (≥60) (n = 180) 2.328 1.193–4.544 0.007842 3.693 (n = 155) 1.634–8.349 0.00169 (2.475e-06)
Polyps present (n = 138) 2.518 1.03–6.155 0.03877    
Gender (Male vs. Female) (n = 180) 1.662 0.930–2.967 0.07991    
Location (rectum vs. Colon) (n = 176) 1.07 0.4935–2.318 0.8656    
Stage (III/IV vs. I/II) (n = 176) 1.95 1.073–3.543 0.0251    
Metastasis presence (n = 155) 3.398 1.82–6.343 0.0002934 3.813 (n = 155) 2.032–7.156 3.08e-05 (2.475e-06)
Lymph node infiltration (n = 179) 1.725 0.978–3.042 0.05665    
Tumor size (T3/T4 vs. T1/T2) (n = 179) 1.746 0.6899–4.417 0.206    
MSI vs. MSS (n = 179) 1.076 0.5948–1.947 0.8092    
Late stage vs. early stage (n = 164) 3.876 0.9389–16 0.04349    
Methylation (methylated vs unmethylated) (n = 165)
CEP55 - cg25314624 1.3444 0.3213–5.626 0.6842    
FOXD3 – cg15617155 ND      
FOXF2 - cg12221475 1.893 0.8455–4.236 0.1146    
GNAO1- cg00866976 0.8484 0.4304–1.673 0.6347    
 cg10273340 0.8404 0.4161–1.697 0.6275    
GRIA4 - cg00343633 0.4816 0.1483–1.563 0.2138    
 cg03225817 0.6222 0.1924–2.012 0.4238    
 cg07972135 0.6185 0.2206–1.734 0.3564    
 cg23559689 0.6887 0.1662–2.853 0.605    
KCNA5 - cg16897114 1.91 0.4558–8.002 0.3682    
Expression (upregulated vs down-regulated)
 CEP55 1.089 0.3344–3.549 0.8871    
 FOXD3 1.859 0.4483–7.711 0.3853    
 FOXF2 ND      
 GNAO1 0.9207 0.2222–3.815 0.9092    
 GRIA4 3.409 0.8084–14.38 0.07561    
 KCNA5 1.859 0.4483–7.711 0.3853    
  1. CIMP the CpG island methylator phenotype, n number of samples, MSI microsatellite instability, MSS microsatellite stable, ND not determinable