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Table 4 Cox proportional hazards model on TCGA dataset

From: Genes CEP55, FOXD3, FOXF2, GNAO1, GRIA4, and KCNA5 as potential diagnostic biomarkers in colorectal cancer

 

Univariate analysis

Multivariate analysis

 

hazard ratio

95% confidence interval

p-value

hazard ratio

95% confidence interval

p-value (p-value of model)

Cluster (CIMP vs. Non-CIMP (n = 180)

1.182

0.6763–2.065

0.5593

   

Age (≥60) (n = 180)

2.328

1.193–4.544

0.007842

3.693 (n = 155)

1.634–8.349

0.00169 (2.475e-06)

Polyps present (n = 138)

2.518

1.03–6.155

0.03877

   

Gender (Male vs. Female) (n = 180)

1.662

0.930–2.967

0.07991

   

Location (rectum vs. Colon) (n = 176)

1.07

0.4935–2.318

0.8656

   

Stage (III/IV vs. I/II) (n = 176)

1.95

1.073–3.543

0.0251

   

Metastasis presence (n = 155)

3.398

1.82–6.343

0.0002934

3.813 (n = 155)

2.032–7.156

3.08e-05 (2.475e-06)

Lymph node infiltration (n = 179)

1.725

0.978–3.042

0.05665

   

Tumor size (T3/T4 vs. T1/T2) (n = 179)

1.746

0.6899–4.417

0.206

   

MSI vs. MSS (n = 179)

1.076

0.5948–1.947

0.8092

   

Late stage vs. early stage (n = 164)

3.876

0.9389–16

0.04349

   

Methylation (methylated vs unmethylated) (n = 165)

CEP55 - cg25314624

1.3444

0.3213–5.626

0.6842

   

FOXD3 – cg15617155

ND

     

FOXF2 - cg12221475

1.893

0.8455–4.236

0.1146

   

GNAO1- cg00866976

0.8484

0.4304–1.673

0.6347

   

 cg10273340

0.8404

0.4161–1.697

0.6275

   

GRIA4 - cg00343633

0.4816

0.1483–1.563

0.2138

   

 cg03225817

0.6222

0.1924–2.012

0.4238

   

 cg07972135

0.6185

0.2206–1.734

0.3564

   

 cg23559689

0.6887

0.1662–2.853

0.605

   

KCNA5 - cg16897114

1.91

0.4558–8.002

0.3682

   

Expression (upregulated vs down-regulated)

 CEP55

1.089

0.3344–3.549

0.8871

   

 FOXD3

1.859

0.4483–7.711

0.3853

   

 FOXF2

ND

     

 GNAO1

0.9207

0.2222–3.815

0.9092

   

 GRIA4

3.409

0.8084–14.38

0.07561

   

 KCNA5

1.859

0.4483–7.711

0.3853

   
  1. CIMP the CpG island methylator phenotype, n number of samples, MSI microsatellite instability, MSS microsatellite stable, ND not determinable