Fig. 3

Non-synonymous and pLoF variants among EMCA to non-cancer control cohort. a For each gene with at least two variants in both EMCA and NCC, the ratio of non-synonymous variants across the EMCA cohort was divided by those in the NCC after adjusting for differences in cohort size. Orange, blue and red lines are used to delineate 2, 1 and 0.5 fold EMCA burden relative to the NCC cohort. b The total number of rare non-synonymous variants from each cohort for each gene. c and d the same as a and b, respectively, except pLoF variants were used