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Fig. 1 | BMC Medical Genomics

Fig. 1

From: Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

Fig. 1

UBR1 and OGDHL show significant APA changes in LOAD. a Bar chart showing mean percentage of significant 3’UTR lengthening (red bars) and 3’UTR shortening (green bars) events between each LOAD patient and control hippocampus derived RNA samples through DaPars analysis (PDUI > 0.25, Fisher’s exact Test, p < 0.05). The error bars indicate standard deviation from comparisons of 4 control samples. The mean number (n) of identified APA events for each LOAD patient are indicated underneath the chart. b Table showing the enrichment of biological processes identified with Gene Ontology Analysis using the PANTHER platform in genes exhibiting 3’UTR lengthening (upper three rows) and 3’UTR shortening (bottom three rows). c List of ten gene examples that show 3’UTR lengthening (red) or 3’UTR shortening (green) in LOAD samples compared to two or more control samples. d Genome browser view of UBR1 as an example gene that shows 3’UTR shortening in LOAD (blue tracks) compared to control (CTRL, green tracks). Annotated miRNA target sites in the UBR1 3’UTR are indicated by yellow boxes below the gene structure. e Genome browser view of OGDHL showing 3’UTR lengthening in LOAD (blue tracks) compared to control (CTRL, green tracks). In d & e, the proximal and distal poly (A) sites are shown as orange boxes and the length of the alternative UTR (aUTR) is indicated below the gene structure. The length of the genome browser windows shown is indicated above in kilo bases (kb) between the two arrows

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