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Fig. 3 | BMC Medical Genomics

Fig. 3

From: Alternative cleavage and polyadenylation of genes associated with protein turnover and mitochondrial function are deregulated in Parkinson’s, Alzheimer’s and ALS disease

Fig. 3

APA Regulation in sPD. a Bar chart showing the mean percentage of 3’UTR lengthening (red) and shortening (green) APA events in SP-D compared to each of the three control samples identified with DaPars analysis (PDUI > 0.25, Fisher’s exact Test p < 0.05). Error bars show standard deviation between the 3 comparisons. The mean number of APA events identified for each comparison is indicated by n below the chart. The percent of statistically significant APA events are labelled. b Venn diagrams showing the overlaps between the identified APA events for each of the S-PD vs control samples. Each shade of green represents a comparison to a different control sample C1, C2 or C3. c Genome browser view depicting the 3’UTR lengthening in CHURC1 gene that shows lengthening in each S-PD sample (blue tracks) compared to control samples (C, green tracks). The proximal and distal poly(A) sites are shown as orange boxes and the length of the alternative UTR (aUTR) is indicated below the gene structure. The length of the genome browser windows shown is indicated above in kilo bases (kb) between the two arrows

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