Fig. 2

Output of CoMutPlotter. The mutation profile of custom cohort is displayed as a heatmap in the main body of the plot, using different glyphs and colors to reveal diverse type of gene mutations in different patients. The significantly mutated genes identified by MutSigCV are displayed as bar chart along the left axis of the plot, ordered according to negative q-values in log transformations, which can also be ordered according to gene mutation frequencies. Clinical information is also displayed as heatmap. At the lower portion of the plot, contributions of 30 COSMIC mutational signatures are rendered as percentage stacked bar chart